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. 2018 Oct 23;9:2417. doi: 10.3389/fimmu.2018.02417

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Copyright © 2018 Agrawal, Streata, Pei, Weiner, Kotze, Bandermann, Lozza, Walzl, du Plessis, Ioana, Kaufmann and Dorhoi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vitro generated human MDSCs maintain suppressive activity following Mtb infection. Proliferation of polyclonally stimulated, CFSE-labeled T-cells co-cultured with naïve (nMDSCs) (A,B) and Mtb-infected (MOI 10) MDSCs (iMDSCs) (C,D) for 72 h. Number of T-cells was kept constant for all conditions with varying amounts of added MDSC; no MDSCs (0:1), 1/4th MDSCs (1:4) and equal MDSCs (1:1). Representative histograms are presented for one donor (E,F). Each symbol corresponds to a single donor, shown are median±IQR. Data are pooled from 2 independent experiments (n = 6 individuals); paired Student's t-test, ^**p ≤ 0.01, ^***p ≤ 0.001, ^****p ≤ 0.0001.