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. 2018 Oct 23;9:1494. doi: 10.3389/fphys.2018.01494

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Copyright © 2018 Egli-Spichtig, Zhang and Perwad.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mineral homeostasis, renal function and inflammation parameters in mice with FA-AKI. (A) Plasma iFGF23, (B) phosphate, (C) BUN, (D) creatinine and (E) 1,25(OH)₂D levels, as well as relative renal (F) Cyp27b1, (G) Cyp24a1, (H) Klotho, (I) Tnf and (J) Tgfb mRNA expression in vehicle (open triangle) and FA (black squares) treated mice after 24 h. Gus was used as housekeeping gene and values were normalized to vehicle group. Five to eight mice per group. Student’s t-test ^∗ p < 0.05. Pearson correlation, R²- and p-values of linear regression analysis with 95% confidence interval for (K) plasma 1,25(OH)₂D and iFGF23, (L) plasma iFGF23 and renal Tnf mRNA expression, (M) plasma 1,25(OH)₂D and renal Tnf mRNA expression. Ten to eleven mice. ^∗p < 0.05.