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. 2018 Oct 23;9:1494. doi: 10.3389/fphys.2018.01494

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Copyright © 2018 Egli-Spichtig, Zhang and Perwad.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fgf23 and Vdr mRNA expression in different organs in mice with FA-AKI and correlation between tissue specific Fgf23, Vdr and renal Tnf expression. Relative (A) Fgf23 and (B) Vdr mRNA expression in bone, spleen, thymus and heart in vehicle (triangle) and FA-treated (squares) mice after 24 h. 18SrRNA (bone, spleen, thymus) or Gus (heart) were used as housekeeping genes and values were normalized to vehicle group. Five to eight mice per group. Student’s t-test ^∗p < 0.05. (C) Pearson correlation, R²- and p-values of linear regression analysis for Fgf23 and Vdr mRNA expression within the same organ as well as between organ specific Fgf23 mRNA and renal Tnf mRNA expression. Ten to eleven mice. ^∗p < 0.05.