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. 2018 Oct 29;8:15940. doi: 10.1038/s41598-018-34386-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted ™use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparative performances of predictors of CKD progression. (A) When comparing the performances of albuminuria and the CKD273 classifier in each eGFR stratum, CKD273 classifier outperformed albuminuria in patients with eGFR > 70 ml/min/1.73 m². (B) The CKD273 subclassifiers performed better in predicting rapid CKD progression in the strata of patients with eGFR > 60 ml/min/1.73 m². (C) The CKD273 subclassifiers developed for specific ranges of eGFR were statistically superior to CKD273 classifier in strata 1 and 3. (D) The performance of the best of either CKD273 classifier (strata corresponding to an eGFR > 70 ml/min/1.73 m²) or albuminuria (eGFR < 70 ml/min/1.73 m²) in each stratum was compared with that of the CKD273 subclassifiers, finding an improvement of the latter in strata of patients with eGFR > 60 ml/min/1.73 m², that reached statistical significance in patients with eGFR > 80 ml/min/1.73 m². The horizontal axis displays the difference between the AUC of both comparators for each figure. ^*P < 0.05 and ^#P < 0.001 vs the contrasted variable.