Table 3.

Prediction of rapid CKD progression.

Baseline eGFR stratum (eGFR)	AUC (95% CI) in the CKD273 subclassifier generated in the training set	Best performing CKD273 subclassifier in this eGFR stratum (validation set)**	AUC (95% CI) for best performing CKD273 subclassifier in this eGFR stratum (validation set)	AUC (95% CI) for albuminuria	AUC (95% CI) for CKD273	KFRE AUC (95% CI) for ESRD at 2 years	KFRE AUC (95% CI) for ESRD at 5 years
1 (≥80)	0.920 (0.892–0.943)	60–69	0.741 (0.683–0.793)	0.636 (0.591–0.679)	0.719 (0.677–0.759)	0.514 (0.468–0.559)	0.604 (0.559–0.648)
2 (70–79)	0.810 (0.767–0.848)	60–69	0.797 (0.743–0.844)	0.568 (0.517–0.619)	0.714 (0.666–0.759)	0.557 (0.505–0.607)	0.610 (0.559–0.659)
3 (60–69)	0.842 (0.792–0.884)	≥80	0.778 (0.738–0.815)	0.685 (0.624–0.740)	0.684 (0.624–0.740)	0.524 (0.462–0.586)*	0.511 (0.449–0.573)*
4 (50–59)	1.000 (0.971–1.000)	40–49	0.824 (0.712–0.906)	0.773 (0.690–0.843)	0.751 (0.666–0.823)	0.712 (0.624–0.789)	0.700 (0.612–0.778)
5 (40–49)	0.958 (0.879–0.992)	50–59	0.728 (0.741–0.803)	0.871 (0.766–0.940)	0.726 (0.603–0.828)	0.824 (0.711–0.906)	0.824 (0.711–0.906)
6 (30–39)	0.985 (0.929–0.999)	40–49	0.728 (0.605–0.830)	0.789 (0.683–0.872)	0.623 (0.508–0.729)	0.688 (0.574–0.787)	0.688 (0.574–0.787)
7 (<30)	0.949 (0.880–0.985)	30–39	0.690 (0.577–0.789)	0.728 (0.623–0.818)	0.534 (0.425–0.641)*	0.591 (0.481–0.694)*	0.591 (0.481–0.695)*

Area under the curve (AUC) and 95% confidence interval (95% CI) of the performance of the CKD273 subclassifiers in the training and in the best validation set. Performances of albuminuria and the CKD273 classifier are also displayed. eGFR expressed as ml/min/1.73 m². The Kidney Failure Risk Equation (KFRE) allows estimating the risk of progression to end-stage renal disease (ESRD) within a fixed temporal horizon. ^*P-values were non-significant.

**Number indicates in which training set was the CKD273 subclassifier generated that performed best in the validation set for the stratum shown in column 1.