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. 2018 Oct 29;8:15922. doi: 10.1038/s41598-018-34156-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Maltol attenuated cisplatin-induced morphological changes. (A,B) H&E staining and PAS stain of kidney sections from normal group, cisplatin group, maltol (50 mg/kg) + cisplatin group and maltol (100 mg/kg) + cisplatin group. Note: The condensation of the cell necrosis (green arrow) and protein cast (yellow arrow) in cisplatin mice. Red arrows refer to vacuolization of the renal cortex (magnification ×400). The renal injury score (C) was determined. All values were expressed as mean ± S.D. ^**p < 0.01 vs. normal group; ^#p < 0.05, ^##p < 0.01 vs. cisplatin group.