Table 1.
Effects of maltol on body weights, kidney indices, and serum biochemical markers in mice.
| Groups | Dosage (mg/kg) | Body weights (g) | Kidney Index (mg/g, × 100) | CRE (µmol/L) | BUN (mmol/L) | NGAL (mg/mL) | |
|---|---|---|---|---|---|---|---|
| Initial | Final | ||||||
| Normal | — | 31.68 | 32.40 | 1.50 | 40.69 ± 4.89 | 8.50 ± 1.12 | 1.27 ± 0.24 |
| Cisplatin | — | 32.34 | 26.86** | 2.13** | 162.46 ± 24.37** | 36.24 ± 2.49** | 3.05 ± 0.61** |
| Cisplatin + maltol | 50 | 29.89 | 28.99 | 1.53## | 32.41 ± 10.26## | 13.38 ± 3.57## | 1.62 ± 0.39## |
| Cisplatin + maltol | 100 | 30.65 | 29.16# | 1.48## | 37.77 ± 10.25## | 8.87 ± 1.08## | 1.88 ± 0.27## |
| Maltol-alone | 100 | 29.95 | 30.45 | 1.61 | 23.64 ± 9.04* | 9.01 ± 1.19 | 1.14 ± 0.30 |
Values represent the mean ± S.D., n = 8; **p < 0.01, *p < 0.05 vs. normal group; ##p < 0.01, #p < 0.05 vs. cisplatin group.