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. 2018 Oct 29;8:15970. doi: 10.1038/s41598-018-34361-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Central diseases and network communities. (A) Diseases emerging as topologically central in men and/or women. The number of appearances (in different strata), the corresponding ages, and the specific condition (chronic or non-chronic) are shown. The dotted lines indicate diseases found to be common to men and women. (B) Disease network for women aged 65–69 years and depicting diseases (ICD-10 codes) identified as central in this gender. The node corresponding to “Diabetes mellitus” (not central) is also indicated (blue font). The node sizes reflect centrality value and their colors indicate communities. Edge thickness is proportional to the magnitude of the RR estimation; black indicates RR > 1.6 and green indicates RR < 0.8. Disease prevalence is shown by font colors as indicated in the inset. (C) Network communities appearing in at least two consecutive strata in men or women. The disease roots of each community are depicted in the insets.