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. 2018 Oct 30;4:59. doi: 10.1038/s41421-018-0059-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Reconstruction of HSPCs in B-NSG mice. Flow cytometry plots show percentage of reconstituted human CD45⁺ leukocytes, CD3⁺ T cells, CD19⁺ B cells and Mac1⁺ myeloid cells in B-NSG mice with the injection of control cells, human CD34-positive cells exposed to CFO, HGF, CFO + HGF and uncultured cells. b Reconstruction of HSPCs in B-NSG mice after 4- and 8-week post-transplantation. *P < 0.05. Data represents the mean ± SD. ns, non-significant. c The frequency of human SRCs in uncultured HSPCs and the progeny of the equivalent number of cells treated with control, CFO, HGF, CFO + HGF or SR1. Poisson statistical analysis of data from Supplementary Table S3. Shapes represent the percentage of negative mice for each dose of cells. Solid lines indicate the best-fit linear model for each data set. Dotted lines represent 95% confidence intervals. C, CHIR-99021; F, Forskolin; O, OAC1; HGF, stem cell factor (SCF) and thrombopoietin (TPO)