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. 2018 Oct 29;8:15961. doi: 10.1038/s41598-018-34280-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Association of in vitro derived peripheral sensory neurons and human Schwann cells. (a–f) Confocal z-stack reconstructions of donor Schwann cells (a–c, donor #29, 7 months old and d–f, donor #31, 15 months old) and in vitro differentiated peripheral sensory neuron co-cultures. Numerous S100B⁺ Schwann cells (arrowheads) align continuously with NEFH⁺ neurites (arrows) following one week of co-culture (a and c, 21 DIV) and over time the Schwann cells become intimately associated with the radiating axonal bundles (b and e, 28 DIV; c and f, 35 DIV). All images were derived from at least three independent co-culture experiments. Additional overview images are presented in Supplementary Fig. 2. Abbreviations: DIV, days in vitro. Scale bar: (a–f) 5μm.