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. 2018 Oct 29;8:15913. doi: 10.1038/s41598-018-34277-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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miRNA profile and differential expression analysis. The graph shows the most abundant miRNAs in mice cortex samples, where 50% of all the reads are identified as seven miRNAs (miR-181a, miR-26a, miR-30, miR-125a/b, miR-486a/b) (A). We showed the condition-specific patterns of the expression of the miRNAs in the mice cortex samples (B). Validation of high throughput data by sensitivity levels of the NGS and RT-qPCR techniques indicate that miR-181a is the most abundant miRNA species and miR-96 is the lowest in both protocols (C). Analysis of miRNAs’ stability under our specific conditions (D). The profile of the miRNAs with a differential expression in the three study comparisons (TLR4-KO + EtOH vs. KO; WE vs. WT; KO vs. WT) was assessed.