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. 2018 Oct 29;8:15913. doi: 10.1038/s41598-018-34277-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The interactome PPI (protein-protein interaction) network of miR-183C and the miR-200 family in alcohol-induced neuroinflammation in the WT and TLR4-KO mice cortex. (A) The diagram shows the different proteins regulated by miR183C and the miR-200 family, and the main proteins involved in alcohol effects (in red), including TLR4 (in blue). (B) The RT-qPCR results show the mRNA expression levels of Nav1.3, Trpv1, Bdnf, Cdca2, Sirt1, Smad3, Mapk14, Lrp6 and Il1r1. n = 10–11 independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 (Student’s t-test) (B).