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. 2018 Oct 29;8:15981. doi: 10.1038/s41598-018-34425-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Sequence analysis of Hp_TH2099 CagA. (a) Amino acid sequences for the EPIYA-repeat regions of canonical East Asian CagA, Hp_TH2099 CagA, and canonical Western CagA were aligned using Clustal W. Amino acid variations in Hp_TH2099 CagA are indicated in dark blue and light blue bold letters. (b) Phylogenetic tree based on the nucleotide sequence of the Hp_TH2099 cagA gene (shown in a red circle) with 199 full-length cagA genes extracted from the GenBank database (left). Positions of East Asian cagA, Western cagA and J-Western cagA were indicated in green line, yellow line, and blue line, respectively. Magnified view of the black dotted box in left figure (right). Hp_TH2099 and other closely related cagA genes were shown. The tree is drawn to scale with branch lengths in the same units as those of the evolutionary distances used to infer the phylogenetic tree. The evolutionary distance was computed in the units of the number of base substitutions per site.