Table 2.
Plasmodium vivax Recurrences Within 1 Year of Follow-up
| Treatment Arm | No. | Total Recurrences in 1 y, No. (%) | Median No. of Recurrences (Range) | Total Effect HR (95% CI) |
P Value | Follow-up Time, y | Rate of Recurrence/PY (95% CI) |
|---|---|---|---|---|---|---|---|
| AS | 224 | 722 (54) | 2 (0–14) | Comparator | 159 | 4.51 (4.19–4.85) | |
| CQ | 222 | 587 (43) | 2 (0–13) | 0.77 (.65–.91) | .002 | 167 | 3.45 (3.18–3.75) |
| CQ + PMQ | 198 | 40 (3) | 0 (0–2) | 0.06 (.04–.08) | <.001 | 154 | 0.26a (.19–.36) |
Abbreviations: AS, artesunate; CI, confidence interval; CQ, chloroquine; HR, hazard ratio; PMQ, primaquine; PY, person-years.
aRate of relapse: rate of recurrence minus rate of recurrence in the CQ + PMQ arm (under the assumption that all recurrences in the CQ-PMQ group are new infections, and that the risk of infection is equivalent across treatment groups).