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. 2018 Aug 31;67(10):1523–1532. doi: 10.1093/cid/ciy327

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Published by Oxford University Press for the Infectious Diseases Society of America 2018.

This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 1. — Different antigenic patterns of human postvaccination sera with or without detectable H3-specific preexisting immunity. A and B, Normalized hemagglutination inhibition (HAI) geometric mean titers (GMTs) in pediatric (A) or adult (B) subjects with or without detectable H3-specific preexisting immunity. Postvaccination HAI GMTs were normalized to vaccine strain A/Hong Kong/4801/2014 (HK/4801)-specific GMTs in the same subpopulation without detectable preexisting immunity. C–F, Antigenic maps constructed using postvaccination HAI titers from the same pediatric (C and D) or adult (E and F) subjects with or without detectable H3-specific preexisting immunity. Each gridline (horizontal and vertical) in the antigenic maps represents 1 antigenic unit distance corresponding to a 2-fold difference in HAI titers. G, Antigenic distances (average ± standard error of the mean [SEM]) of H3 viruses determined in each antigenic map and correlation analysis within the same population. Correlation coefficients of 1, −1, and 0 represent a perfect positive correlation, a perfect negative correlation, and no correlation, respectively. Both pediatric and adult participants were vaccinated with the 2015/16 egg-based inactivated, nonadjuvanted, trivalent or quadrivalent vaccines. Egg-grown H3 viruses in the testing panel included clade 1, A/Uruguay/716/2007X175C (175C); clade 3C.1, A/Texas/50/2012 (TX/50); clade 3C.2a, HK/4801, A/Singapore/KK934/2014 (SGPKK934), A/Fiji/2/2015 (Fiji/2), A/South Australia/09/2015 (SA/09), A/South Australia/21/2015 (SA/21), A/Victoria/503/2015 (Vic/503), A/Brisbane/47/2015 (Bris/47), and A/Brisbane/82/2015 (Bris/82); clade 3C.3, A/New York/39/2012 (NY/39); clade 3C.3a, A/Switzerland/9715293/2013 (SWZ/13), A/North Carolina/13/2014 (NC/13), and A/Palau/6759/2014 (PA/14); clade 3C.3b, A/Victoria/511/2015 (Vic/511).