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. 2018 Aug 31;67(10):1523–1532. doi: 10.1093/cid/ciy327

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Published by Oxford University Press for the Infectious Diseases Society of America 2018.

This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 5. — H3 antigenic patterns determined by ferret antisera with different exposure histories. A–D, Normalized H3-specific ferret cross-reactive hemagglutination inhibition (HAI) geometric mean titers (GMTs). Egg-grown H3 viruses in the testing panel included clade 1, A/Uruguay/716/2007X175C (175C); clade 3C.1, A/Texas/50/2012 (TX/50); clade 3C.2a, A/Hong Kong/4801/2014 (HK/4801), A/Singapore/KK934/2014 (SGPKK934), A/Fiji/2/2015 (Fiji/2), A/South Australia/09/2015 (SA/09), A/South Australia/21/2015 (SA/21), A/Victoria/503/2015 (Vic/503), A/Brisbane/47/2015 (Bris/47), and A/Brisbane/82/2015 (Bris/82); clade 3C.3, A/New York/39/2012 (NY/39); clade 3C.3a, A/Switzerland/9715293/2013 (SWZ/13), A/North Carolina/13/2014 (NC/13), and A/Palau/6759/2014 (PA/14); clade 3C.3b, A/Victoria/511/2015 (Vic/511). Sera were collected from ferrets infected with HK (A), SWZ/HK (B), TX/SWZ/HK (C), or 175C/TX/SWZ/HK (D). (Please see the Figure 2 legend for descriptions of influenza virus strains.) Ferret HAI GMTs specific for individual H3 viruses are normalized to HK/4801-specific GMT with the red dotted lines indicating 50% response. E–H, Antigenic maps constructed using H3-specific HAI titers of ferret antisera. Each gridline (horizontal and vertical) in the antigenic maps represents 1 antigenic unit distance corresponding to a 2-fold difference in HAI titers. I, Antigenic distances (with standard error of the mean [SEM]) of H3 viruses determined in each ferret antigenic map and correlation analysis relative to ferret HK antisera-derived antigenic map. Correlation coefficients of 1, −1, and 0 represent a perfect positive correlation, a perfect negative correlation, and no correlation, respectively.