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. 2018 Oct 30;67(Suppl 1):S66–S77. doi: 10.1093/cid/ciy634

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© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — Analysis of long-term persistence of immune priming to each of the poliovirus serotypes long-term post a single fractional-dose inactivated poliovirus vaccine (IPV) intradermal (i.d.). (A) IPV challenge was done in 4 macaques 300 days after single fractional-dose IPV (i.d.). (B) IPV challenge was done in 4 macaques 480 days after fractional-dose IPV (i.d.). Neutralizing antibody (NT Ab) titers (left panel), immunoglobulin (Ig) G titers (middle panel), and memory B cell frequencies (right panel) are shown for individual macaques. Blue lines indicate those macaques that generated NT Abs after the single IPV immunization. Red lines indicate those macaques that failed to generate neutralization titers after the single IPV immunization. The center panel shows the plasma IgG-binding Ab titers measured in these individual macaques for all 3 poliovirus vaccine antigens; data are represented as the en-point titer. Abbreviations: Ig, immunoglobulin; IPV, inactivated poliovirus vaccine.