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. 2018 Oct 23;9:2428. doi: 10.3389/fimmu.2018.02428

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Copyright © 2018 Novkovic, Onder, Cheng, Bocharov and Ludewig.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Multi-layered microarchitecture of the LN. (A) Schematic overview of the LN architecture and cellular organization. Zoom-in panels represent confocal microscopy images stained for indicated markers. BF, B cell follicle; IF, inter-follicular; SCS, subcapsular sinus; HEV, high endothelial venule; FDC, follicular dendritic cell; TRC, T cell zone fibroblastic reticular cell; MRC, marginal reticular cell; BEC, blood endothelial cell; LEC, lymphatic endothelial cell. (B) Network graphs of the TRC network and equivalent network models; Watts-Strogatz small-world network, Erdos-Renyi random network and 1D ring lattice network. Colors indicate nodes with low (blue) or high (red) betweenness centrality.