Table 3.

Univariate and multivariate analyses of disease free survival according to prognostic variables in cervical cancer patients (n = 336).

Risk factor	Univariate		Multivariate
	Hazard ratio [95%CI]	p-value	Hazard ratio [95%CI]	p-value
FIGO stage (>IIB)	2.44 [1.24–4.82]	0.010*	2.29 [0.72–7.25]	0.160
Cell type (Adeno vs. SCC)	2.88 [1.62–5.14]	<0.001*	2.18 [0.75–6.28]	0.151
LN metastasis	4.13 [2.31–7.38]	<0.001*	4.52 [1.64–12.46]	0.004*
Tumor size (>4 cm)	1.7 [0.92–3.15]	0.092	0.65 [0.18–2.32]	0.508
PM involvement	2.24 [1.05–4.81]	0.038*	2.87 [0.85–9.66]	0.088
AGR2High	4.02 [1.7–9.49]	0.002*	3.16 [1.32–7.58]	0.010*
BRD7High	0.47 [0.26–0.84]	0.010*	0.5 [0.28–0.92]	0.025*
POM121High	0.5 [0.24–1.05]	0.066	0.52 [0.25–1.08]	0.078
PAUFHigh/AGR2High	7.17 [2.45–20.94]	<0.001*	13.2 [3.72–46.89]	<0.001*
PAUFHigh/BRD7Low	5.47 [2.4–12.48]	<0.001*	4.16 [1.57–11.02]	0.004*
PAUFHigh/POM121Low	9.21 [2.12–40.09]	0.003*	15.46 [2.68–89.08]	0.002*
AGR2High/BRD7Low	11.88 [2.77–50.95]	0.001*	8.15 [1.79–37.16]	0.007*
AGR2High/POM121Low	79227176.83 [0–Inf]	0.997	47108676.12 [0–Inf]	0.996
POM121High/BRD7High	0.34 [0.15–0.8]	0.013*	0.38 [0.16–0.91]	0.030*
AGR2High/POM121Low/BRD7Low	251011694.96 [0–Inf]	0.998	349083474.2 [0–Inf]	0.998

FIGO, International Federation of Gynecology and Obstetrics; SCC, squamous cell carcinoma; AC, adenocarcinoma; LN, lymph node; PM, parametrium.

^*Significant at the level of p < 0.05.