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. 2018 Oct 23;12:360. doi: 10.3389/fncel.2018.00360

FIGURE 2.

FIGURE 2

Altered synaptic transmission onto CA1 pyramidal neurons in MD F1 mice compared to CD F1 mice. (A) sIPSCs. Upper: sample recordings of sIPSCs in CD F1 (left, black) and MD F1 (right, red) mice. Lower: reduced sIPSC frequencies (left) and normal sIPSC amplitudes (right) in CA1 pyramidal neurons of MD F1 mice. Unpaired t-test, P < 0.05 for frequency, P > 0.05 for amplitude, n = 12 cells from five CD F1 mice and n = 13 cells from five MD F1 mice. The frequencies and amplitudes of mIPSCs (B), sEPSCs (C), and mEPSCs (D) were not different between MD and CD F1 mice. Insets, sample traces recorded in CA1 pyramidal neurons of MD (red) and CD (black) F1 mice. In (B), n = 12 cells from five CD F1 mice and n = 11 cells from five MD F1 mice. In (C,D), n = 9 cells from five CD F1 mice and n = 11 cells from five MD F1 mice. Scale bars: 100 pA, 250 ms. ∗P < 0.05 means significant difference. All data are shown as means ± SEM.

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