FIGURE 4.

Overexpression of Kcnmb2 in CA1 region of dorsal hippocampus rescued alterations in synaptic transmission onto CA1 pyramidal neurons in MD F1 mice. (A) Sample sIPSCs recorded from virus-infected CA1 pyramidal neurons (GFP⁺) in MD and CD F1 mice. Comparisons of sIPSC frequencies (B) and sIPSC amplitudes (C) between CD and MD F1 neurons infected by control or Kcnmb2 virus. Two-way ANOVA followed by Tukey’s multiple comparisons test, CD-control n = 25, MD-control n = 24, CD-Kcnmb2 n = 10, and MD-Kcnmb2 n = 10 neurons from six mice per group. ^∗P < 0.05, ^∗∗P < 0.01 means significant difference. All data are shown as means ± SEM.