Table 2.

Associations between γδ T cells and protection in experimental Plasmodium infection models in mice.

Species	Strain	Characteristic	Finding	References
Plasmodium yoelii	Py17X (PyNL)	Non-lethal	• γδ T cells not essential for clearance of blood-stage parasites but do contribute to control of liver stages	Tsuji et al. (50); McKenna et al. (51)
Plasmodium berghei	ANKA	Lethal	• Mice with γδ T cells depleted by monoclonal antibody are protected from cerebral malaria • γδ T cells affect CD8α+ dendritic cells in the liver, antigen-specific CD8+ T cell responses in the liver and spleen, and development of protective immunity	Yañez et al. (52); Zaidi et al. (46)
Plasmodium berghei	XAT	Non-lethal	• γδ T cells essential for parasite clearance • CD40 signaling between γδ T cells and dendritic cells contributes to control of parasitemia • γδ T cells contribute to humoral immunity	Inoue et al. (53); Inoue et al. (54)
Plasmodium chabaudi	AS	Non-lethal in C57BL/6 mice	• γδ T cells expand after infection and produce IFNγ • Mice deficient in γδ T cells have higher parasitemia • γδ T cells expanding later in infection protect against parasite recrudescence	Van der Hyde et al. (55); Langhorne et al. (6); Seixas and Langhorne (7); Weidanz et al. (8); Weidanz et al. (56); Mamedov et al. (9)