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. 2018 Jul 1;31(4):275–282. doi: 10.1293/tox.2018-0027

Fig. 1.

Fig. 1.

Effect of EEBGP administration on hepatocellular necrosis. A: Representative photographs of the liver after 24 h of APAP 800 mg/kg administration. A-(a): Control group. Centrilobular hepatocellular necrosis with inflammatory cell infiltration is observed. A-(b): EEBGP group. Hepatocellular necrosis with inflammatory cell infiltration is limited to the region around the central veins. CV, central vein; PT, portal triad. Tissue specimens were stained with hematoxylin and eosin (100×). B: Percentage of necrosis area in the liver of the control and EEBGP groups. The vertical bars represent the mean values and standard deviation for each group. *p<0.05 versus the control group, assessed by Student’s t-test. C: The serum ALT and AST levels in the EEBGP and control groups. The vertical bars represent the mean values and standard deviation for each group. EEBGP, ethanol extract of Brazilian green propolis; APAP, N-acetyl-p-aminophenol; ALT, alanine aminotransferase; AST, aspartate aminotransferase