Table 2.
Odds Ratio Estimates and 95% Confidence Intervals from Logistic Regression Models Using Lasso-Selected Variables Only for Fast and Timely Filling
| Variable | Fast filling (≤ 7 days); OR (95% CI) | Timely filling (≤ 30 days); OR (95% CI) |
|---|---|---|
| Therapeutic area (antihypertensive) | 1.20 (1.08, 1.33) | NA |
| Therapeutic area (asthma/COPD) | NA | 0.72 (0.65, 0.79) |
| Asthma | 0.69 (0.62, 0.77) | 0.81 (0.75, 0.88) |
| Diabetes | 0.71 (0.64, 0.79) | 0.66 (0.61, 0.71) |
| Hypertension | NA | 0.83 (0.77, 0.90) |
| Congestive heart failure | NA | 0.80 (0.69, 0.94) |
| Hyperlipidemia | 0.85 (0.77, 0.94) | 0.93 (0.87, 1.00) |
| Number of refills | 1.03 (1.01, 1.05) | NA |
| Number of providers | NA | 0.93 (0.92, 0.95) |
| Number of current medications | 1.30 (1.27, 1.33) | 1.27 (1.25, 1.29) |
| Total number of medications | NA | 1.05 (1.04, 1.07) |
| Average out-of-pocket amount (per $10) | 0.97 (0.96, 0.99) | 0.98 (0.97, 0.99) |
| Age (per 5 years) | NA | 1.04 (1.02, 1.06) |
| Low-income subsidy in at least 1 month | NA | 1.28 (1.17, 1.39) |
| Median household income in zip code (per $10,000) | NA | 1.02 (1.01, 1.03) |
| Quantity (per 10 pills) | 0.97 (0.96, 0.98) | NA |
| New to therapeutic area | NA | 0.80 (0.68, 0.94) |
| Race: White | NA | 0.89 (0.81, 0.98) |
| Primary language: unavailable | NA | 0.69 (0.51, 0.94) |
| Body mass index: > 30 | NA | 0.82 (0.76, 0.88) |
| Prescriber is a primary care physician | NA | 1.08 (1.01, 1.15) |
| Dispense as written on index prescription | NA | 0.34 (0.26, 0.43) |
| Medication frequency: daily | NA | 1.77 (1.56, 2.01) |
| Medication frequency: > daily | NA | 1.09 (0.95, 1.24) |
| Interaction terms | ||
| Female × relationship status: not in a relationship vs. others | NA | 1.05 (0.99, 1.13) |
| Abnormal HbA1c* × therapeutic area: diabetes | NA | 1.65 (1.22, 2.27) |
| Abnormal LDL† × therapeutic area: hyperlipidemia | NA | 1.44 (1.22, 1.71) |
| Abnormal SBP‡ × therapeutic area: hypertension | 1.53 (1.25, 1.88) | 1.54 (1.36, 1.75) |
| Number of refills × quantity (per 100 pills) | NA | 0.97 (0.95, 0.98) |
| Quantity (per 10 pills) × med frequency: > daily | NA | 0.96 (0.95, 0.97) |
NA indicates that the variable was not selected by lasso for that outcome and was therefore not included in the relevant model
*Defined as HbA1c ≥ 8.0
†Defined as LDL ≥ 130
‡Defined as SBP ≥ 150