FIG 3.

Fra-2 expression in osteoblasts increases circulant myeloid progenitor cell numbers. (A) Liver and spleen weights per body weight from Fra-2^Ob-tet and littermate mice (n = 6). (B) FACS dot plots and quantification of hematopoietic stem cells (LSK, Lin⁻ Sca1⁺ c-Kit⁺) and myeloid progenitors (Lin⁻ IL-17Ra⁻ Sca1⁻ c-Kit⁺) in 10-week-old Fra-2^Ob-tet and littermate mouse blood (n = 4 to 8). (C) Quantification of myeloid progenitor and CD11b⁺ cell proliferation in blood from Fra-2^Ob-tet and littermate mice (n = 6). (D) FACS dot plots and quantification of myeloid progenitor apoptosis in blood from Fra-2^Ob-tet and littermate mice (n = 6). Data represent the mean values ± SEM. *, P < 0.05 (by unpaired t test).