TABLE 3.
NI titers in sera from a subset of pigs at 0 days postchallenge
| Study | Groupa | NI titer against NA of indicated virusb |
||
|---|---|---|---|---|
| OH/04 | IA/14 (n = 15 NA aa differences)c | NY/11 (n = 21 NA aa differences)c | ||
| 1 | NV-IN/13 | <10, <10, <10, <10, <10 | <10, <10, <10, <10, <10 | <10, <10, <10, <10, <10 |
| OH/04WIV-IN/13 | <10, <10, <10, <10, <10 | <10, <10, <10, <10, <10 | <10, <10, <10, <10, <10 | |
| OH/04LAIV-IN/13 | 10, 10, 80, 40, 20 | 10, 20, 40, 160, 10 | <10, <10, <10, 10, <10 | |
| 2 | NV-IA/14 | <10, <10, <10, <10, <10 | <10, <10, <10, <10, <10 | <10, <10, <10, <10, <10 |
| IA/14WIV-IA/14 | <10, <10, <10, <10, <10 | <10, <10, <10, <10, <10 | <10, <10, <10, <10, <10 | |
| IA/14LAIV-IA/14 | 20, 40, <10, 20, 20 | 20, 20, <10, 20, 20 | <10, <10, <10, <10, <10 | |
| NV-NY/11 | <10, <10, <10, <10, <10 | <10, <10, <10, <10, <10 | <10, <10, <10, <10, <10 | |
| IA/14WIV-NY/11 | 10, <10, <10, <10, <10 | 10, <10, <10, <10, <10 | <10, <10, <10, <10, <10 | |
| IA/14LAIV-NY/11 | 20, 40, 10, 10, 40 | <10, 10, <10, <10, 40 | <10, 10, <10, <10, <10 | |
| Serum paneld | OH/04WIV | 80, 20 | ||
a
The vaccine and challenge strains used in each group are defined in Table 1. WIV and LAIV contain the NA of OH/04. NV, nonvaccinated; WIV, adjuvanted-whole inactivated virus vaccine; LAIV, live-attenuated influenza A virus vaccine.
b
A titer of ≥20 was considered positive. Boldface indicates positive titers. NI, neuraminidase inhibition; NA, neuraminidase.
c
Number of amino acid (aa) differences out of 469 total amino acids in the NA compared to the sequence of OH/04 NA.
d
OH/04 antisera generated previously used as part of a panel of sera to generate antigenic maps of H3 IAV-S (13).