FIG 1.

MALT1 deficiency delays morbidity caused by CVS-11. Malt1^−/− (n = 10) and Malt1^+/+ (n = 10) littermates were infected intranasally with CVS-11 virus. (A, B) Cumulative clinical signs (A) and survival rates (B) were assessed. All Malt1^−/− and Malt1^+/+ mice developed severe disease and had to be euthanized. Malt1^−/− mice developed the first symptoms later than Malt1^+/+ mice and had to be sacrificed 2 to 10 days later than the Malt1^+/+ mice. Results are representative of two independent experiments. (C) Typical disease signs observed in a rabid mouse: rough hair coat, paralysis, isolation from the group.