FIG 8.

Impact of pharmacological or genetic inhibition of MALT1 catalytic activity on survival of CVS-11-infected mice. (A) Schematic overview of the pharmacological approach. Wild-type mice were treated twice a day with mepazine (n = 7) or a control solution (0.9% NaCl in water) (n = 7) starting at day −2 before virus inoculation until the end of the experiment. Two days after the first treatment, mice were inoculated intranasally with CVS-11 virus and monitored daily for signs of disease. (B) Survival curves of mepazine-treated mice infected with CVS. (C) Survival curves of protease-dead MALT1 knock-in mice infected with CVS.