FIG 1.

NKT cells can play potent antiviral roles in anti-HSV-1 immunity. (A, B, and C) Eight- to 10 week-old age- and gender-matched wild-type or CD1d^−/− BALB/c mice (n, 5 each) were anesthetized with ketamine and xylazine and were infected via their corneas with 5 million HSV-1 strain F viruses. (A) The severity of periocular disease was scored in each group of mice at the indicated time points postinfection. Asterisks indicate significant differences (P < 0.05) between the two mouse groups at the indicated time points. (B) Representative eye images for BALB/c mice at 10 days postinfection. Areas boxed in red were examined for scoring. (C) Mouse eyes were swabbed at the indicated time points postinfection, and viral titers in swabs from a representative mouse in each group were determined by plaque assays in Vero cells. (D, E, and F) Eight- to 10-week-old wild-type or CD1d^−/− C57BL/6 (B6) mice were infected with 50 million HSV-1 strain F viruses. (D) The severity of periocular disease was scored at the indicated time points postinfection. (E) Representative eye images for C57BL/6 mice at 10 days postinfection. (F) Viral titers in eye swabs at 1 day postinfection.