FIG 4.

NKT cells possess potent anti-HSV-1 function in hCD1d-KI mice. Eight- to 10-week-old hCD1d-KI mice were injected intravenously with a vehicle control or with 2 μg of α-GalCer in PBS. Two days posttreatment, mice were ocularly infected with 50 million HSV-1 strain F viruses. (A) The severity of periocular disease was scored at the indicated time points postinfection. (B) Virus titers in mouse eye swabs at the indicated time points postinfection were determined by plaque assays in Vero cells. aGC, α-GalCer.