FIG 5.

The US3 gene of HSV-1 is a critical pathogenicity factor targeting NKT cells. (A and B) Eight- to 10-week-old hCD1d-KI mice were infected with 50 million HSV-1 strain F or US3Δ (US3D) viruses. (A) The severity of periocular disease was scored at 10 days postinfection. (B) Virus titers in mouse eye swabs at 1 day postinfection were determined by plaque assays in Vero cells. (C) Eight- to 10-week-old hCD1d-KI or CD1d^−/− mice were infected with 50 million HSV-1 US3Δ viruses. Virus titers in eye swabs at 1 day postinfection were determined by plaque assays in Vero cells.