FIG 5.

Immune breadth is largely determined by HA antigen selection. (A) Selected groups of HA-Nps were tested as bivalent or trivalent vaccines in mice by immunization at week 0 and week 3 with AF03 adjuvant. HAI titers (log₂) were measured from mouse serum at week 6. (B) CA09 and NC99 influenza inactivated vaccines (IIV) were tested as monovalent and bivalent vaccines with either SAS or AF03 adjuvant, as indicated. Dashed lines mark the limit of detection (3.32). Horizontal gray bars mark the 1:40 to 1:80 ranges as a visual aid. Red asterisks indicate matched strains.