Skip to main content
. Author manuscript; available in PMC: 2019 Mar 19.
Published in final edited form as: Nature. 2018 Sep 19;562(7728):578–582. doi: 10.1038/s41586-018-0543-y

Extended Data Figure 9. AP treatment attenuates tau phosphorylation.

Extended Data Figure 9.

a, Ponceau S loading controls for western blot lysates of 6-month-old whole brain total-tau (left) and phosphorylated tau (S202/T205; right) shown in Figure 3a. b, Quantification of westerns blot analysis from 6-month-old whole brain for soluble tau (left), soluble phosphorylated tau (S202/T205; middle), and insoluble phosphorylated tau (S202/T205; right). Biologically independent animal numbers are indicated, data are from ≥ 3 independent experiments. c, Immunostaining of 6-month-old cortex for phosphorylated tau protein at T231 (top) and S396 (bottom; n = 4 mice per group, 2 independent experiments). Scale bar, 100µm. Data are mean ± s.e.m. ***P < 0.001 (one-way ANOVA with Tukey’s multiple comparisons test). Exact P values can be found in the accompanying source data file.