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. Author manuscript; available in PMC: 2019 Mar 19.
Published in final edited form as: Nature. 2018 Sep 19;562(7728):578–582. doi: 10.1038/s41586-018-0543-y

Extended Data Figure 2. AP-mediated clearance selectively removes senescent cells that accumulate in brains of PS19;ATTAC mice.

Extended Data Figure 2.

Expression of senescence markers from 6-month-old female hippocampus (left) and cortex (cortex) either vehicle (–AP) or AP20187 (+AP) treated assessed by RT-qPCR (animal numbers indicated in the legend; normalized to ATTAC –AP group). p21 is also known as Cdkn1a; Pai1 is also known as Serpine1. Data are mean ± s.e.m. *P < 0.05; **P < 0.01; ***P < 0.001 (one-way ANOVA with Tukey’s multiple comparisons test). Exact P values can be found in the accompanying source data file.