Table 2. Risks and hazard ratios for major bleeding, CRNM bleeding and recurrent VTE among patients receiving apixaban and warfarin as outpatient therapy for VTE.

	No. Patients	No. Events	% Evented	Risk per 100 PY	HR	95% CI	p -Value
Major bleeding
All
Apixaban	17,878	295	1.7	4.2	0.75	0.64–0.87	< 0.001
Warfarin	17,878	412	2.3	5.5	–	–	–
Gastrointestinal
Apixaban	17,878	111	0.6	1.6	0.72	0.57–0.92	0.009
Warfarin	17,878	160	0.9	2.2	–	–	–
Intra-cranial
Apixaban	17,878	24	0.1	0.3	0.97	0.56–1.69	0.920
Warfarin	17,878	26	0.1	0.3	–	–	–
Other
Apixaban	17,878	160	0.9	2.3	0.74	0.60–0.90	0.003
Warfarin	17,878	226	1.3	3.0	–	–	–
CRNM bleeding
All
Apixaban	17,878	1,257	7.0	18.0	0.77	0.71–0.83	< 0.001
Warfarin	17,878	1,688	9.4	22.7	–	–	–
Gastrointestinal
Apixaban	17,878	385	2.2	5.5	0.88	0.76–1.00	0.053
Warfarin	17,878	460	2.6	6.2	–	–	–
Other
Apixaban	17,878	874	4.9	12.5	0.73	0.67–0.79	< 0.001
Warfarin	17,878	1,238	6.9	16.7	–	–	–
Recurrent VTE
Apixaban	17,878	403	2.3	5.8	0.80	0.70–0.91	< 0.001
Warfarin	17,878	521	2.9	7.0	–	–	–

Abbreviations: CI, confidence interval; CRNM, clinically relevant non-major; HR, hazard ratio; PY, patient-years; VTE, venous thromboembolism.