Table 1.
Baseline characteristics of all patients and diagnostic subgroups.
| MPA | GPA | All | |||
|---|---|---|---|---|---|
| N=47 | N=38 | N=85 | P∗ | ||
| Males | 27 (57.4) | 26 (68.4) | 53 (62.4) | 0.30 | |
| Age (years) | 62 (28-80) | 52 (22-77) | 58 (22-80) | 0.004 | |
| Hypertonia | 14 (29.8) | 8 (21.1) | 22 (25.9) | 0.36 | |
| CVD | 8 (17.0) | 3 (7.9) | 11 (12.9) | 0.21 | |
| Creatinine (μmol/l) | 250 (63-2332) | 164 (56-1600) | 208 (56-2332) | 0.02 | |
| GFR (ml/min/1.73 m2) | 17 (1-91) | 35 (3-120) | 24 (1-120) | 0.01 | |
| ANCA | PR3-ANCA | 6 (12.8) | 34 (89.5) | 40 (47.1) | <0.001 |
| MPO-ANCA | 41 (87.2) | 4 (10.5) | 45 (52.9) | ||
| BVAS | 15 (11-26) | 19 (5-39) | 17 (5-39) | <0.001 | |
| Proteinuria (g/day) | <0.5 | 7 (14.9) | 6 (15.8) | 13 (15.3) | 0.31 |
| 0.5-3.0 | 26 (55.3) | 26 (68.4) | 52 (61.2) | ||
| >3.0 | 14 (29.8) | 6 (15.8) | 20 (23.5) | ||
| Organ involvement | Renal | 47 (100) | 38 (100) | 85 (100) | |
| General symptoms∗∗∗ | 33 (70.2) | 34 (89.5) | 67 (78.8) | 0.03 | |
| Lung | 13 (27.7) | 18 (47.4) | 31 (36.5) | 0.06 | |
| ENT | 2 (4.3) | 23 (60.5) | 25 (29.4) | <0.001 | |
| Skin | 6 (12.8) | 9 (23.7) | 15 (17.6) | 0.19 | |
| Eyes/mucous membranes | 3 (6.4) | 11 (28.9) | 14 (16.5) | 0.01 | |
| Nervous system | 3 (6.4) | 5 (13.2) | 8 (9.4) | 0.49∗∗ | |
| Abdominal | 5 (10.6) | 1 (2.6) | 6 (7.1) | 0.22∗∗ | |
| Cardiac | 2 (4.3) | 0 (0.0) | 2 (2.4) | 0.50∗∗ |
Data are presented as the median (range) for continuous nonnormal variables and as the number (%) for categorical variables.
GPA, granulomatosis with polyangiitis; MPA, microscopic polyangiitis (including two patients with renal limited vasculitis); CVD, cardiovascular disease; GFR, glomerular filtration rate; ANCA, anti-neutrophil cytoplasmic antibody; PR3, proteinase 3; MPO, myeloperoxidase; BVAS, Birmingham vasculitis activity score; ENT, ear, nose, and throat.
∗P values indicate the comparison between GPA and MPA. Mann-Whitney U test was used for nonnormal continuous variables; Chi-squared test and Fisher's exact test (∗∗) were used for categorical variables.
∗∗∗ General symptoms: fever, weight loss, arthralgia, myalgia.