Table 2.
(A) Histopathological class of AAV in renal biopsies according to diagnosis and ANCA specificity. (B) Baseline characteristics of patients per histopathological class.
| Histopathological class of AAV in renal biopsies | ||||||||
|---|---|---|---|---|---|---|---|---|
| Focal | Crescentic | Sclerotic | Mixed | All | ||||
| N=29 | N=22 | N=16 | N=17 | N=84 | P∗ | |||
| (A) | Diagnosis | MPA∗∗ | 11 (23.9) | 10 (21.7) | 14 (30.4) | 11 (23.9) | 46 | |
| GPA | 18 (47.2) | 12 (31.6) | 2 (5.3) | 6 (15.8) | 38 | 0.01 | ||
| ANCA | MPO | 10 (22.7) | 9 (20.5) | 14 (31.8) | 11 (25.0) | 44 | 0.003 | |
| PR3 | 19 (47.5) | 13 (32.5) | 2 (5.0) | 6 (15.0) | 40 | |||
|
| ||||||||
| (B) | Males | 17 (58.6) | 15 (68.2) | 11 (68.8) | 9 (52.9) | 52 (61.9) | 0.71 | |
| GFR, ml/min/1.73 m2 | 60 (5-120) |
14 (2-86) |
12 (1-38) |
21 (5-88) |
24 (1-120) |
<0.001 | ||
| Age, years | 55 (23-78) |
50 (23-76) |
67 (39-80) |
60 (22-80) |
58 (22-80) |
0.02 | ||
| Proteinuria >3 g/day | 2 (6.9) | 4 (18.2) | 8 (50.0) | 5(29.4) | 19 (22.6) | 0.01 | ||
Data are presented as the median (range) for continuous nonnormal variables and as the number (%) for categorical variables.
AAV, ANCA-associated vasculitis; ANCA, anti-neutrophil cytoplasmic antibody; MPA, microscopic polyangiitis (including two patients with renal limited vasculitis); GPA, granulomatosis with polyangiitis; MPO, myeloperoxidase; PR3, proteinase 3; GFR, glomerular filtration rate.
∗ Kruskal-Wallis test was used for nonnormal continuous variables and Chi-squared test was used for categorical variables.
∗∗ The renal biopsy of one MPA patient was not available.