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. 2018 Oct 29;11:770. doi: 10.1186/s13104-018-3885-5

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Non-target analyses of phosphorothioated oligonucleotides (PSOs) in deproteined plasma. a Total ion chromatogram (TIC), data dependent acquisition (DDA) Explorer (Time versus Precursor MS/Charge for DDA dependents), DDA Explorer filtered by m/z 94.936 with 10 ppm mass tolerance of deproteinated plasma with 4.5 µg/mL oligo dT. b TIC, DDA Explorer, and DDA Explorer filtered by m/z 94.936 with 10 ppm mass tolerance of 100 ng/mL oligo 1 in deproteinated plasma with 4.5 µg/mL oligo dT. Phosphorothioated (PS) oligomers were selectively detected in a heavy biological matrix containing a 45 times higher concentration of a non-PS oligomer without any sequence information