Table 4.
Associations with NHGRI-EBI asthma SNPs in COPDGene childhood asthma GWAS
| NHW a | Gene | SNP | Locus | Effect Allele | OR | Rsq | Freq (%) | P-value b,d | Adj P-value e |
| (385 cases, 4979 controls) | IL1RL1 | rs10197862 f | 2q12.1 | A | 1.45 | 1.00 | 0.85 | 0.002 | 0.011 |
| TSLP | rs1837253g | 5q22.1 | T | 1.07 | 0.75 | 0.414 | 1.000 | ||
| RAD50 | rs2244012f | 5q31.1 | G | 1.05 | 0.78 | 0.579 | 1.000 | ||
| IL13 | rs1295686f | 5q31.1 | T | 1.22 | 0.80 | 0.026 | 0.180 | ||
| C11orf30-LRRC32 | rs7130588g | 11q13.5 | G | 1.23 | 0.64 | 0.008 | 0.054 | ||
| GSDMB | rs2305480f | 17q21.1 | G | 1.22 | 0.44 | 0.009 | 0.060 | ||
| GSDMA | rs3894194f | 17q21.1 | A | 1.18 | 0.94 | 0.47 | 0.029 | 0.201 | |
| AA a | Gene | SNP | Locus | Effect Allele | OR | Rsq | Freq (%) | P-value b,d | Adj P-value e |
| (325 cases, 2342 controls) | IL1RL1 | rs10197862f | 2q12.1 | A | 1.10 | 0.98 | 0.74 | 0.344 | 1.000 |
| TSLP | rs1837253g | 5q22.1 | C | 1.11 | 0.28 | 0.283 | 1.000 | ||
| RAD50 | rs2244012f | 5q31.1 | G | 1.05 | 0.57 | 0.603 | 1.000 | ||
| IL13 | rs1295686f | 5q31.1 | T | 1.16 | 0.64 | 0.102 | 0.717 | ||
| C11orf30-LRRC32 | rs7130588g | 11q13.5 | G | 1.23 | 0.80 | 0.035 | 0.247 | ||
| GSDMB | rs2305480f | 17q21.1 | G | 1.03 | 0.13 | 0.817 | 1.000 | ||
| GSDMA | rs3894194f | 17q21.1 | G | 1.02 | 0.88 | 0.69 | 0.846 | 1.000 | |
| Meta-analysis a | Gene | SNP | Locus | Effect Allele | OR | I 2 | P-value c,d | Adj P-value e | |
| (710 cases, 7321 controls) | IL1RL1 | rs10197862 f | 2q12.1 | A | 1.23 | 70 | 0.006 | 0.042 | |
| TSLP | rs1837253g | 5q22.1 | C | 1.01 | 45 | 0.910 | 1.000 | ||
| RAD50 | rs2244012f | 5q31.1 | G | 1.05 | 0 | 0.447 | 1.000 | ||
| IL13 | rs1295686 f | 5q31.1 | T | 1.19 | 0 | 0.006 | 0.043 | ||
| C11orf30-LRRC32 | rs7130588 g | 11q13.5 | G | 1.23 | 0 | 0.001 | 0.005 | ||
| GSDMB | rs2305480f | 17q21.1 | G | 1.17 | 27 | 0.018 | 0.125 | ||
| GSDMA | rs3894194f | 17q21.1 | A | 1.10 | 57 | 0.113 | 0.794 |
Abbreviations: NHGRI-EBI National Human Genome Research Institute - European Bioinformatics Institute; SNP single nucleotide polymorphism; GWAS genome-wide association study; NHW Non-Hispanic Whites; AA African American; OR odds ratio of the effect allele; Rsq estimation of imputation quality; Freq frequency of effect allele; I2 heterogeneity index; a Each population was run as an independent analysis, and then combined in the meta-analysis: b Logistic regression based on case control status; c Fixed effect meta-analysis weighted by inverse variance. d Adjusted for sex, genetic ancestry. e Bonferroni correction for seven tests, SNPs with adjusted p < 0.05 in Bold. f SNP is in the reported gene, g SNP is near the reported gene