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. 2018 Oct 23;10:311. doi: 10.3389/fnagi.2018.00311

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Copyright © 2018 Shinozaki, Braun, Hing, Ratanatharathorn, Klisares, Duncan, Jellison, Heinzman, Nagahama, Close, Sabbagh, Dlouhy, Howard, Kawasaki and Cho.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Epigenetics hypothesis–the missing link in the cascade from aging to delirium? Both animal and human models are shown. The role of epigenetics (yellow arrows) is not well understood and thus warrants further investigation.