Table 1.
Correlations of age and DNAm levels from blood samples obtained from the independent GTP cohort.
| CPG info | GTP | |||||
|---|---|---|---|---|---|---|
| CpG | Chr | Position | Gene | N | r | p-value |
| cg10650821 | 6 | 31543686 | TNF | 265 | −0.41 | 2.8544E-12 |
| cg08553327 | 6 | 31543647 | TNF | 265 | −0.40 | 1.4059E-11 |
| cg01569083 | 6 | 31543289 | TNF | 265 | −0.39 | 5.208E-11 |
| cg26729380 | 6 | 31543655 | TNF | 265 | −0.38 | 1.106E-10 |
| cg04472685 | 6 | 31545473 | TNF | 265 | −0.36 | 2.3131E-09 |
| cg04425624 | 6 | 31543565 | TNF | 265 | −0.35 | 4.8768E-09 |
| cg21222743 | 6 | 31543545 | TNF | 265 | −0.34 | 1.2343E-08 |
| cg03037030 | 6 | 31543300 | TNF | 265 | −0.33 | 2.7845E-08 |
| cg21467614 | 6 | 31543638 | TNF | 265 | −0.33 | 5.3752E-08 |
| cg21370522 | 6 | 31543219 | TNF | 265 | −0.32 | 7.6408E-08 |
| cg10717214 | 6 | 31543557 | TNF | 265 | −0.32 | 7.7839E-08 |
| cg12681001 | 6 | 31543540 | TNF | 265 | −0.32 | 8.6829E-08 |
| cg11484872 | 6 | 31543169 | TNF | 265 | −0.31 | 2.3968E-07 |
| cg09637172 | 6 | 31545252 | TNF | 265 | −0.29 | 1.7632E-06 |
| cg02137984 | 6 | 31545898 | TNF | 265 | −0.29 | 1.8168E-06 |
| cg15703690 | 7 | 22766992 | IL6 | 265 | 0.27 | 1.0416E-05 |
| cg26736341 | 6 | 31545342 | TNF | 265 | −0.25 | 3.3831E-05 |
| cg06825478 | 6 | 31546067 | TNF | 265 | −0.25 | 4.1973E-05 |
| cg15989608 | 6 | 31545321 | TNF | 265 | −0.25 | 5.3427E-05 |
| cg05952498 | 6 | 31545257 | TNF | 265 | −0.25 | 5.4834E-05 |
| cg20477259 | 6 | 31544960 | TNF | 265 | −0.23 | 0.00016172 |
| cg01360627 | 6 | 31544931 | TNF | 265 | −0.23 | 0.00022076 |
| cg23384708 | 6 | 31544934 | TNF | 265 | −0.22 | 0.00036899 |
| cg17755321 | 6 | 31546085 | TNF | 265 | −0.21 | 0.00058042 |
| cg17741993 | 6 | 31544694 | TNF | 265 | −0.19 | 0.00145946 |
| cg15106030 | 4 | 74528435 | IL8 | 265 | −0.19 | 0.00184398 |
| cg19124225 | 6 | 31545836 | TNF | 265 | −0.17 | 0.005378 |
| cg20157753 | 2 | 1.14E+08 | IL1B | 265 | 0.17 | 0.00588717 |
| cg07998387 | 7 | 22767571 | IL6 | 265 | −0.17 | 0.00603186 |
| cg24452282 | 6 | 31542740 | TNF | 265 | −0.17 | 0.0064941 |
| cg23149881 | 2 | 1.14E+08 | IL1B | 265 | −0.14 | 0.01833347 |
| cg18007641 | 4 | 74641828 | IL8 | 265 | −0.14 | 0.02275773 |
| cg04392234 | 4 | 74608458 | IL8 | 265 | −0.14 | 0.02666244 |
| cg17067544 | 7 | 22765321 | IL6 | 265 | −0.14 | 0.02757188 |
| cg06850158 | 4 | 74567419 | IL8 | 265 | −0.13 | 0.02829831 |
| cg18553677 | 7 | 22701635 | IL6 | 265 | −0.13 | 0.03362868 |
| cg27531490 | 6 | 31542459 | TNF | 265 | −0.13 | 0.03493842 |
| cg03310594 | 7 | 22704316 | IL6 | 265 | −0.12 | 0.04311163 |
| cg11814672 | 4 | 74600153 | IL8 | 265 | −0.11 | 0.07068166 |
| cg03246791 | 2 | 1.14E+08 | IL1B | 265 | −0.11 | 0.0751379 |
TNFalpha, IL-1beta, IL-6, and IL-8 were tested with a total of 74 CpGs. Orange-highlighted CpGs were also nominally significant at NSG blood samples. Blue-highlighted CpGs were also nominally significant (light blue) at NSG brain Neu (–) samples (glia) or showed trends (dark blue) in the same direction (see Table 2). Most of these significant CpGs are from TNFalpha, other than few exceptions (gray shading).