Fig. 1.

SwissMTB molecular diagnostics workflow. DNA (and RNA) is extracted from a tumor biopsy (and paired control tissue, e.g., blood) and sequenced. The resulting data is analyzed to detect genetic alterations (only in the tumor sample), which are associated with potential therapy options. Suitable therapies and clinical trial options are summarized in a clinical report, which is returned to the clinician and discussed in the molecular tumor board