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. Author manuscript; available in PMC: 2018 Oct 30.
Published in final edited form as: J Am Chem Soc. 2018 Aug 16;140(34):10639–10643. doi: 10.1021/jacs.8b04638

Figure 2. A proposed model for the assembly of the large bilayer within DNA-origami barrels (90 nm outer diameter).

Figure 2.

Bringing the 11-nm nanodiscs close to each other to within several nanometers is a critical first step. Adding excess lipids solubilized in detergent destabilizes and induces fusion of the neighboring nanodiscs. Next, the intermediate-sized nanodiscs fuse, perhaps aided by transient deformation of the barrel into an ellipsoid contour, to yield a single large bilayer nanodisc. Scale bar, 50 nm.