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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Hypertension. 2018 Oct;72(4):909–917. doi: 10.1161/HYPERTENSIONAHA.118.11666

Figure 1. Ubiquitin(1–76) and ubiquitin(1–74) antagonize the pro-proliferative effects of the CXCR4-receptor agonist SDF-1α in SHR and WKY cardiac fibroblasts.

Figure 1.

Figure illustrates the concentration-dependent effects of ubiquitin(1–76) (panels A and B) and ubiquitin (1–74) (panels C and D) on proliferation of SHR (panels A and C) and WKY (panels B and D) cardiac fibroblasts stimulated with SDF-1α (10 nmol/L). In the absence of ubiquitins, a four-day treatment with SDF-1α significantly increased proliferation (cell number) of both SHR and WKY cardiac fibroblasts. In the absence of SDF-1α, a four-day treatment with either of the two ubiquitins did not affect cardiac fibroblast proliferation in either SHR or WKY cardiac fibroblasts. However, both ubiquitin(1–76) and ubiquitin(1–74) significantly antagonized the pro-proliferative effect of SDF-1α. Values are means ± SEM.