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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Circ Heart Fail. 2018 Sep;11(9):e004571. doi: 10.1161/CIRCHEARTFAILURE.117.004571

Figure 7. PDE5i Normalizes SV Serum-Induced Transcriptional Changes Associated with Cardiac Hypertrophy and Dysfunction in vitro.

Figure 7.

(A) Activation z-scores of significantly dysregulated cardiotoxicity pathways in NF versus SV serum-treated NRVMs compared to NF+PDE5i vs SV+PDE5i serum-treated NRVMs. (B) Heat map summary of the genes predicted to be involved in cardiac hypertrophy signaling based on IPA, that were normalized by PDE5i (average fold change relative to NF, n=3 NF, n=3 NF+PDE5i, n=3 SV, n=3 SV+PDE5i in a total of 3 NRVM preparations). (C) Heat map summary of the genes predicted to be involved in cardiac dysfunction signaling based on IPA, that were normalized by PDE5i (average fold change relative to NF, n=3 NF, n=3 NF+PDE5i, n=3 SV, n=3 SV+PDE5i in a total of 3 NRVM preparations).