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. 2018 Oct 29;37:261. doi: 10.1186/s13046-018-0929-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Apigenin and curcumin attenuate IFN-γ-induced STAT1 phosphorylation in human melanoma cells. a-c, A375, A2058, and RPMI-7951 cells were incubated with DMSO, curcumin (25 μM), or apigenin (30 μM) for 4 h and then treated with IFN-γ (10 ng/ml) for indicated times. The levels of STAT1 phosphorylation at Tyr701 and total STAT1 were detected by Western blot analysis. GAPDH was used as a loading control. Line charts on the right show the quantitation data of pSTAT1 by comparing to the levels with 1 min IFN-γ stimulation from the control group (100%) of each cell line. Data were presented as the mean ± S.D. from three independent experiments