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. 2018 Oct 29;37:261. doi: 10.1186/s13046-018-0929-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — Schematic diagram depicting apigenin and curcumin-mediated inhibition of PD-L1 expression in DCs and melanoma cells. Apigenin and curcumin inhibit IFN-γ-induced STAT1 phosphorylation, leading to reduced PD-L1 expression and surface presentation. Apigenin shows stronger effects than curcumin, with the suppression of PD-L1 expression exerting a dual effect via regulating both tumor and antigen presenting cells (DCs)