Table 2.
Summary of predictive values of FC for objective and clinical activity
| AUC for FC | PPV | NPV | Sensitivity | Specificity | |||||
|---|---|---|---|---|---|---|---|---|---|
| >100 | >200 | >100 | >200 | >100 | >200 | >100 | >200 | ||
| UC clinical activity (Mayo clinical score ≥ 3) | 0.83, 95% CI: [0.70–0.97] P < 0.001 | 73 | 73 | 78 | 78 | 91 | 91 | 67 | 67 |
| UC endoscopic activity | 0. 97, 95% CI: [0.91–1] P < 0.001 | 100 | 100 | 100 | 100 | 88 | 88 | 100 | 100 |
| Colonic CD clinical activity (HBI > 4) | 0.72, 95% CI: [0.49–0.95] P = 0.09 | 80 | 84 | 71.4 | 68 | 80 | 83 | 50 | 50 |
| Colonic CD endoscopic activity | 0.95, 95% CI: [0.88–1] P < 0.001 | 67 | 60 | 100 | 100 | 100 | 100 | 67 | 60 |
| Isolated SB CD clinical activity (HBI > 4) | 0.45, 95% CI: [0.13–0.75] P = 0.6 | 50 | 56 | 37.5 | 40 | 71 | 71 | 47 | 56 |
| Isolated SB CD radiographic/endoscopic activity | 0.52, 95% CI [0.22–0.96] P = 0.6 | 75 | 75 | 50 | 53 | 75 | 75 | 50 | 47 |
CD, Crohn's disease; CRP, C‐reactive protein; FC, fecal calprotectin; HBI, Harvey–Bradshaw Index; Isolated SB CD, isolated small bowel CD; PPV, Positive Predictive Value; NPV, Negative Predictive Value; UC, ulcerative colitis.