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. 2018 Oct 23;9:2434. doi: 10.3389/fimmu.2018.02434

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Copyright © 2018 Bhattacharyya, Wang, Tamaki, Shi, Yeldandi, Tsukimi, Yamasaki and Varga.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of TLR4 signaling by TAK242 induces regression of established skin fibrosis. C57/BL6 mice received daily s.c. injections of PBS or bleomycin alone, or TAK242 (10 or 30 mg/kg) or vehicle started after 2 weeks of bleomycin injections. Mice were sacrificed at day 28 and skin was harvested for analysis. (A) Masson's Trichome stain. (a) vehicle, (b) bleomycin for 2 weeks (5 days a week), (c) bleomycin followed by low dose (10 mg/kg), and (d) high dose (30 mg/kg) of TAK242 post-treatment until harvest at 28 days. Representative images. Bar = 25 μm. (B) Dermal thickness (means ± s.d. of five determinations/hpf from five mice/group). (C) Skin hydroxyproline content. One-way analysis of variance followed by Sidak's multiple comparison test.