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. 2018 Oct 23;9:2434. doi: 10.3389/fimmu.2018.02434

Figure 3.

Figure 3

Inhibition of TLR4 signaling by TAK242 induces regression of established lung fibrosis. C57/BL6 mice received daily s.c. injections of PBS or bleomycin alone, or TAK242 (10 or 30 mg/kg) started after 2 weeks of bleomycin injections or vehicle. Mice were sacrificed at day 28 and lung was harvested. (A) Masson's Trichome stain. (a) vehicle, (b) bleomycin for 2 weeks (5 days a week), (c) bleomycin followed by high dose (30 mg/kg) of TAK242 post-treatment until harvest at 28 days. Representative images. Bar = 25 μm. (B) Fibrosis score (Hubner) (13) determined in lungs from 5 hpf per mice. Results are means±s.d. from three mice per group. One-way analysis of variance followed by Sidak's multiple comparison test. (C) Lung hydroxyproline content. One-way analysis of variance followed by Sidak's multiple comparison test.